How Much Does Diphenhydramine Cost in Mexico vs the USA?
Sold in Mexico as BENADRYL 120ML JBE, BENADRYL JARABE 120 ML, Benadryl Jarabe 0.25G 120Ml. Also known by the brand names Benadryl, Dimegan, Nyquil Z, Dramamine, Gelbeck, NyQuil Z and 5 more.
Prices updated:
Available Strengths
Price per unit varies noticeably between doses — worth comparing.
Price per unit by strength (generic)
Showing pharmacy listings for 25mg capsule
Generic pricing — 25mg capsule
Mexico
Prices range $1.51–$26.67 between pharmacies we track — worth comparing.
Difenhidramina 25 mg, 10 Cápsulas Pharmalife.generic$1.51$0.15 / unit
DIFENHIDRAMINA 25 MG 30 CAPSULASgeneric$1.92$0.06 / unit
Gelbeck 25 Mg Caps 10generic$5.50- Gelbeck 25 mg, 10 Cápsulas.generic$5.55$0.55 / unit
Difenhidramina 25Mg 10 Capsgeneric$6.28$0.63 / unit- Nyquil Z 25Mg 15 Capsgeneric$9.23$0.62 / unit
- Nyquil Z 25 Mg 10 Capsgeneric$10.94$1.09 / unit
- NyQuil Z 25 mg, 30 Cápsulas.generic$12.32$0.41 / unit
- Nyquil Z 25Mg 30 Capsgeneric$18.70$0.62 / unit
- Nyquil Z Dispens 25Mg 2Caps C/generic$24.13$12.07 / unit
- NyQuil Z Difenhidramina 25mg 2 Cajas con 30 Cápsulas c/ugeneric$26.67$0.89 / unit
In Mexico, the brand-name product is actually about 281% cheaper than the generic here.
Brand-name pricing — 25mg capsule
Mexico
Prices range $2.21–$26.73 between pharmacies we track — worth comparing.
Difenhidramina 25.0 MG Gelbeck 10 Cápsulas Cajabrand$2.21$0.22 / unit- Yza Difenhidramina 25Mg 10 Capsbrand$2.56$0.26 / unit
Difenhidramina 25mg caja 10 cápsulasbrand$2.73$0.27 / unit
GELBECK 25 MG CAP CAJ C/10brand$4.84$0.48 / unit
Gelbeck 25mg con 10 Cápsulasbrand$5.62$0.56 / unit- Difenhidramina (Gelpharma) 25mg con 10 Cápsulasbrand$5.84$0.58 / unit
Gelbeck 25 mg Difenhidramina 10 ud Cápsulasbrand$7.26- Gelbeck 25mg caja 10 cápsulasbrand$7.61$0.76 / unit
- NyQuil Z 25mg Difenhidramina 10 ud Cápsulasbrand$9.24
- Nyquilz 25 mg Difenhidramina Auxiliar en el Insomnio 30 ud Cápsulasbrand$26.73
Showing pharmacy listings for 25mg tablet
Generic pricing — 25mg tablet
Mexico
Prices range $8.37–$11.53 between pharmacies we track — worth comparing.
Benadryl 25 mg Caja Con 24 Tabletasgeneric$8.37$0.35 / unit- Antihistamínico Benadryl 24 Tableta, 25 mg.generic$9.61$0.40 / unit
BENADRYL 25 MG 24 TABLETASgeneric$10.04$0.42 / unit- Benadryl 25Mg 24 Tabsgeneric$11.53$0.48 / unit
United States
For comparison — here's what the same product typically costs at US pharmacies.
Retail prices range $9.16–$12.94 between pharmacies we track — coupon prices vary too.
generic$12.94$9.16with pharmacy coupon$0.31 / unit- Diphenhydramine Hclgeneric$12.94$9.16with pharmacy coupon$0.31 / unit
- generic$12.94$11.16with pharmacy coupon$0.37 / unit
- Diphenhydramine Hclgeneric$12.94$11.16with pharmacy coupon$0.37 / unit
generic$12.94$0.43 / unit
generic$12.94$0.43 / unit
generic$12.94$0.43 / unit- Diphenhydramine Hclgeneric$12.94$0.43 / unit
- Diphenhydramine Hclgeneric$12.94$0.43 / unit
- Diphenhydramine Hclgeneric$12.94$0.43 / unit
Showing pharmacy listings for 50mg capsule
Generic pricing — 50mg capsule
Difenhidramina 50 mg Oral 20 Caps Marca del Ahorrogeneric$2.50$0.13 / unit
In Mexico, the brand-name product is actually about 2.5% cheaper than the generic here.
Brand-name pricing — 50mg capsule
- Genérico de Marca 50 mg Difenhidramina 20 Cápsulasbrand$2.44$0.12 / unit
Showing pharmacy listings for 50mg tablet
Generic pricing — 50mg tablet
Mexico
Prices range $5.75–$15.31 between pharmacies we track — worth comparing.
- Nitesom-Df 50Mg 8 Tabsgeneric$5.75$0.72 / unit
- Nitesom-DF 50 mg 8 Tabletasgeneric$8.66$1.08 / unit
Nytol De 50 mg Caja Con 8 Tabletas - Difenhidraminageneric$8.78$1.10 / unit- NYTOL 50 MG 8 TABLETASgeneric$11.56$1.45 / unit
- Nytol 50 mg, 8 Tabletas.generic$12.05$1.51 / unit
- Nytol 50 mg con 8 tabletasgeneric$13.77$1.72 / unit
- Nytol 50Mg 8 Tabsgeneric$14.79$1.85 / unit
- Nytol 50 Mg Tab 8generic$15.31
In Mexico, the brand-name product is actually about 30.8% cheaper than the generic here.
Brand-name pricing — 50mg tablet
Mexico
Prices range $1.86–$14.29 between pharmacies we track — worth comparing.
Hidrigort 50mg 8 Tab Difenhidramina Gen 8 Pzbrand$1.86$0.23 / unit- Hidrigort 50mg caja con 8 tabletasbrand$2.09$0.26 / unit
- Nitesom-DF 50 mg Difenhidramina 8 Tabletasbrand$5.75$0.72 / unit
- NITESOM-DF 50MG TAB CAJ C/8brand$5.75$0.72 / unit
- Nytol 50 mg Caja Con 8 Tabletas.brand$8.78$1.10 / unit
- Nytol 50 Mg Tab 8 Pzbrand$13.60$1.70 / unit
- NYTOL 50 mg TAB C/8brand$13.71$1.71 / unit
- Nytol 50mg caja 8 tabletasbrand$14.29$1.79 / unit
Showing pharmacy listings for 270mg tablet
Brand-name pricing — 270mg tablet
Tabletas Benadryl Antihistamínico 270mg con 24 Tabletasbrand$10.52$0.44 / unit
Showing pharmacy listings for capsule
Generic pricing — capsule
Mexico
Prices range $6.68–$41.61 between pharmacies we track — worth comparing.
- Gelbeck 10 cápsulasgeneric$6.68$0.67 / unit
- NyQuil Z Auxiliar en el insomnio ocasional con Difenhidramina 30 cápsulasgeneric$23.18$0.77 / unit
Auxiliar en el insomnio Vick NyQuil Z con Difenhidramina 2 Cajas de 30 Cápsulas c/ugeneric$41.61$1.39 / unit
In Mexico, the brand-name product is actually about 22.2% cheaper than the generic here.
Brand-name pricing — capsule
Mexico
Prices range $6.62–$27.25 between pharmacies we track — worth comparing.
- Cápsulas Gelbeck para Dormir Caja con 10 Cápsulasbrand$6.62$0.66 / unit
- NyQuil Z Auxiliar en el insomnio ocasional con Difenhidramina 10 cápsulasbrand$7.44$0.74 / unit
- Vick Nyquil Z Difenhidramina Capsulas con 30 pzbrand$27.25$0.91 / unit
Showing pharmacy listings for tablet
Generic pricing — tablet
- Benadryl Antihistamínico 24 tabletasgeneric$11.03$0.46 / unit
In Mexico, the generic saves you 71.1% vs the brand-name product.
Brand-name pricing — tablet
Mexico
Prices range $12.48–$12.96 between pharmacies we track — worth comparing.
- Nytol con 8 Tabletasbrand$12.48$1.56 / unit
- Tabletas Nytol Caja con 8 Tabletasbrand$12.96$1.62 / unit
FDA Drug Information
Official prescribing information for Childrens Allergy Relief
Excerpted from the FDA-approved label (Best Choice) — not medical advice. Always read the full label and talk to a pharmacist or doctor before use.
What It's Used For
Uses temporarily relieves these symptoms due to hay fever or other respiratory allergies: ■ sneezing ■ itching of the nose or throat ■ runny nose ■ itchy watery eyes ■temporarily relieves these symptoms due to the common cold: ■ sneezing ■ runny nose
Dosage & Administration
Directions ■ if needed, take every 4-6 hours ■ do not take more than 6 doses in 24-hours children under 4 years of age Do not use children 4 to under 6 years of age Do not use unless directed by a doctor children 6 to under 12 years of age 1 to 2 teaspoonfuls (5 ml to 10 ml)
Warnings
Warnings Do not use ■ with any other product containing diphenhydramine, even one used on skin ■ to make a child sleepy Ask a doctor before use if the child has ■ glaucoma ■ a breathing problem such as chronic bronchitis
Similar Medications
Other forms of Diphenhydramine
Frequently Asked Questions
Is there a generic version of Diphenhydramine?
Yes, Diphenhydramine is available both as a brand-name product and as a generic.
Does the price of Diphenhydramine change with the dose?
Yes - the price per unit for Diphenhydramine (capsule) varies noticeably between the 4 strengths we track. Check the dosage table above to find the best value for your prescription.
How can I save money on Diphenhydramine?
Compare prices for Diphenhydramine across Mexican and US pharmacies above to find the lowest price, and check whether a generic version is available - generics are typically cheaper than the brand-name product.
Data & Disclaimers
Prices last checked: October 3, 2026.
Prices are collected periodically from pharmacy websites and public pricing sources and are shown for general reference only — actual prices can vary by pharmacy, location, and over time. Frontera Rx is not a pharmacy and does not sell medication; we don't provide medical advice. Always confirm the current price and availability with the pharmacy before you buy or travel. Read our full disclaimer.
*NADAC markup is a reference figure: how many times higher a US retail price is than the National Average Drug Acquisition Cost (NADAC), a public wholesale benchmark published by the US government. It reflects one factor in how US retail drug prices are set; we show it as neutral background information, not as a judgment about any pharmacy or program. For this product, the US retail price runs about 12.1× the NADAC reference.